Cancer trends in HIV-infected people may be influenced by changes in group demographics (e.g., aging), in background rates of cancer in the general population, and in the relative risk for cancer in HIV-infected individuals compared with the general population. Now, investigators have used data from the HIV/AIDS Cancer Match Study, which links HIV and cancer registries in seven states, to examine how these factors have influenced time trends for 10 cancers in HIV-infected patients.
Data were evaluated for approximately 275,000 HIV-infected patients (~1,472,000 person-years of follow-up) for 1996 through 2010. During this period, the proportion of follow-up time contributed by people aged ≥50 increased from 13% in 1996–2000 to 27% in 2006–2010. The main cancer trends were:
Increases in the rates of anal, liver, and prostate cancers
Decreases in the rates of Kaposi sarcoma (KS), cervical cancer, non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), and lung cancer
Stable rates of breast and colorectal cancers
The trends for breast, colorectal, liver, lung, and prostate cancers were influenced by aging and other demographic shifts in the HIV-infected population. Liver and lung cancer trends were particularly affected by changes in the background rates in the general population. The decline in KS, NHL, cervical cancer, HL, and lung cancer rates reflected decreases in the relative risks for these malignancies in the HIV-infected population.